Creosote bush lignans for human disease treatment and prevention: Perspectives on combination therapy
Identifieur interne : 001099 ( Main/Exploration ); précédent : 001098; suivant : 001100Creosote bush lignans for human disease treatment and prevention: Perspectives on combination therapy
Auteurs : John Gnabre [États-Unis] ; Robert Bates [États-Unis] ; Ru Chih Huang [États-Unis]Source :
- Journal of Traditional and Complementary Medicine [ 2225-4110 ] ; 2015.
Abstract
The medicinal properties of the most successful plant in the deserts of the western hemisphere, the creosote bush (
Url:
DOI: 10.1016/j.jtcme.2014.11.024
PubMed: 26151022
PubMed Central: 4488564
Affiliations:
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<author><name sortKey="Huang, Ru Chih" sort="Huang, Ru Chih" uniqKey="Huang R" first="Ru Chih" last="Huang">Ru Chih Huang</name>
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<front><div type="abstract" xml:lang="en"><p>The medicinal properties of the most successful plant in the deserts of the western hemisphere, the creosote bush (<italic>Larrea tridentata</italic>
), are evidenced by the long traditional usage of the plants by the Native Americans Indian tribes in Southwestern North America and the Amerindians from South America. The plant is rich in simple bisphenyl lignans and tricyclic lignans known as cyclolignans. These compounds are responsible for many of the pharmacological activities of extracts of the plants. Some of these activities, namely antiherpes, antioxidant, antifungal, and anti-inflammatory, were known a century ago. Only recently have further studies revealed other crucial activities of the same plant molecules as powerful agents against human immunodeficiency virus, human papillomavirus, cancer, neurodegenerative diseases, and symptoms of aging. Molecular mechanisms underlying the antiviral and anticancer activities have been elucidated and involve the inhibition of SP1 dependent gene transcription. This review summarizes the recent findings on creosote bush lignans. We introduce the concept of a cocktail of safe well-characterized natural products from the creosote bush that would represent a bridge between oriental herbal medicines and Western drug-based therapies.</p>
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</TEI>
<affiliations><list><country><li>États-Unis</li>
</country>
<region><li>Arizona</li>
<li>Maryland</li>
</region>
</list>
<tree><country name="États-Unis"><region name="Maryland"><name sortKey="Gnabre, John" sort="Gnabre, John" uniqKey="Gnabre J" first="John" last="Gnabre">John Gnabre</name>
</region>
<name sortKey="Bates, Robert" sort="Bates, Robert" uniqKey="Bates R" first="Robert" last="Bates">Robert Bates</name>
<name sortKey="Huang, Ru Chih" sort="Huang, Ru Chih" uniqKey="Huang R" first="Ru Chih" last="Huang">Ru Chih Huang</name>
</country>
</tree>
</affiliations>
</record>
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